Endocrine Abstracts

Introduction: Acromegaly is a rare disease which results from a GH producing adenoma. Around 70–80% are macroadenomas. The therapeutic options currently available are surgery, radiotherapy (RT) and medical treatment (MT). According to literature microadenomas have a higher remission rate, around 80%.Methods: A retrospective chart review of the patients with acromegaly treated in our centre from 1976 to 2011 was performed. In terms of disease control...

Aims/hypothesis: Several data have shown the association between diabetes type 2 (DM2) and transcription factor 7-like 2 (TCF7L2) gene polymorphisms, in several and different ethnical populations. Although the pathophysiology is not completely clear, it seems that beta and alpha cell functions are abnormal. Up to these days there is no clinical data showing association between TCF7L2 gene polymorphism allele rs7903146 T and beta cell insulin and C-peptide contents in DM2 patie...